Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.
Identifieur interne : 000747 ( Main/Exploration ); précédent : 000746; suivant : 000748Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.
Auteurs : Gema Pereira-Caro [Espagne] ; Christine M. Oliver [Australie] ; Rangika Weerakkody [Australie] ; Tanoj Singh [Australie] ; Michael Conlon [Australie] ; Gina Borges [États-Unis] ; Luz Sanguansri [Australie] ; Trevor Lockett [Australie] ; Susan A. Roberts [États-Unis] ; Alan Crozier [États-Unis] ; Mary Ann Augustin [Australie]Source :
- Free radical biology & medicine [ 1873-4596 ] ; 2015.
English descriptors
- KwdEn :
- Administration, Oral, Adolescent, Adult, Aged, Bifidobacterium (physiology), Biological Availability, Citrus sinensis (chemistry), Drug Compounding, Female, Flavanones (administration & dosage), Flavanones (pharmacokinetics), Fruit and Vegetable Juices, Humans, Male, Middle Aged, Probiotics (administration & dosage), Young Adult.
- MESH :
- chemical , administration & dosage : Flavanones.
- administration & dosage : Probiotics.
- chemistry : Citrus sinensis.
- chemical , pharmacokinetics : Flavanones.
- physiology : Bifidobacterium.
- Administration, Oral, Adolescent, Adult, Aged, Biological Availability, Drug Compounding, Female, Fruit and Vegetable Juices, Humans, Male, Middle Aged, Young Adult.
Abstract
Orange juice (OJ) flavanones are bioactive polyphenols that are absorbed principally in the large intestine. Ingestion of probiotics has been associated with favorable changes in the colonic microflora. The present study examined the acute and chronic effects of orally administered Bifidobacterium longum R0175 on the colonic microflora and bioavailability of OJ flavanones in healthy volunteers. In an acute study volunteers drank OJ with and without the microencapsulated probiotic, whereas the chronic effects were examined when OJ was consumed after daily supplementation with the probiotic over 4 weeks. Bioavailability, assessed by 0-24h urinary excretion, was similar when OJ was consumed with and without acute probiotic intake. Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main urinary flavanone metabolites. The overall urinary excretion of these metabolites after OJ ingestion and acute probiotic intake corresponded to 22% of intake, whereas excretion of key colon-derived phenolic and aromatic acids was equivalent to 21% of the ingested OJ (poly)phenols. Acute OJ consumption after chronic probiotic intake over 4 weeks resulted in the excretion of 27% of flavanone intake, and excretion of selected phenolic acids also increased significantly to 43% of (poly)phenol intake, corresponding to an overall bioavailability of 70%. Neither the probiotic bacterial profiles of stools nor the stool moisture, weight, pH, or levels of short-chain fatty acids and phenols differed significantly between treatments. These findings highlight the positive effect of chronic, but not acute, intake of microencapsulated B. longum R0175 on the bioavailability of OJ flavanones.
DOI: 10.1016/j.freeradbiomed.2015.03.010
PubMed: 25801290
Affiliations:
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Electronic address: maryann.augustin@csiro.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25801290</idno><idno type="pmid">25801290</idno><idno type="doi">10.1016/j.freeradbiomed.2015.03.010</idno><idno type="wicri:Area/PubMed/Corpus">000158</idno><idno type="wicri:Area/PubMed/Curation">000158</idno><idno type="wicri:Area/PubMed/Checkpoint">000158</idno><idno type="wicri:Area/Ncbi/Merge">001A49</idno><idno type="wicri:Area/Ncbi/Curation">001A49</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A49</idno><idno type="wicri:Area/Main/Merge">000747</idno><idno type="wicri:Area/Main/Curation">000747</idno><idno type="wicri:Area/Main/Exploration">000747</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chronic administration of a microencapsulated probiotic enhances the bioavailability of orange juice flavanones in humans.</title><author><name sortKey="Pereira Caro, Gema" sort="Pereira Caro, Gema" uniqKey="Pereira Caro G" first="Gema" last="Pereira-Caro">Gema Pereira-Caro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Technology, Postharvest and Food Industry, IFAPA-Alameda del Obispo, Córdoba, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Technology, Postharvest and Food Industry, IFAPA-Alameda del Obispo, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Oliver, Christine M" sort="Oliver, Christine M" uniqKey="Oliver C" first="Christine M" last="Oliver">Christine M. Oliver</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Weerakkody, Rangika" sort="Weerakkody, Rangika" uniqKey="Weerakkody R" first="Rangika" last="Weerakkody">Rangika Weerakkody</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Tanoj" sort="Singh, Tanoj" uniqKey="Singh T" first="Tanoj" last="Singh">Tanoj Singh</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Conlon, Michael" sort="Conlon, Michael" uniqKey="Conlon M" first="Michael" last="Conlon">Michael Conlon</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Adelaide, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Borges, Gina" sort="Borges, Gina" uniqKey="Borges G" first="Gina" last="Borges">Gina Borges</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, University of California at Davis, Davis, CA 95616, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, University of California at Davis, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sanguansri, Luz" sort="Sanguansri, Luz" uniqKey="Sanguansri L" first="Luz" last="Sanguansri">Luz Sanguansri</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Lockett, Trevor" sort="Lockett, Trevor" uniqKey="Lockett T" first="Trevor" last="Lockett">Trevor Lockett</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, North Ryde, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, North Ryde, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Susan A" sort="Roberts, Susan A" uniqKey="Roberts S" first="Susan A" last="Roberts">Susan A. Roberts</name><affiliation wicri:level="2"><nlm:affiliation>Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA 30313, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, GA 30313</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, University of California at Davis, Davis, CA 95616, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, University of California at Davis, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Augustin, Mary Ann" sort="Augustin, Mary Ann" uniqKey="Augustin M" first="Mary Ann" last="Augustin">Mary Ann Augustin</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Food & Nutrition Flagship, Werribee, VIC, Australia. Electronic address: maryann.augustin@csiro.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Food & Nutrition Flagship, Werribee, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Free radical biology & medicine</title><idno type="eISSN">1873-4596</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Bifidobacterium (physiology)</term><term>Biological Availability</term><term>Citrus sinensis (chemistry)</term><term>Drug Compounding</term><term>Female</term><term>Flavanones (administration & dosage)</term><term>Flavanones (pharmacokinetics)</term><term>Fruit and Vegetable Juices</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Probiotics (administration & dosage)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Flavanones</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Probiotics</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Flavanones</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bifidobacterium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Biological Availability</term><term>Drug Compounding</term><term>Female</term><term>Fruit and Vegetable Juices</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Orange juice (OJ) flavanones are bioactive polyphenols that are absorbed principally in the large intestine. Ingestion of probiotics has been associated with favorable changes in the colonic microflora. The present study examined the acute and chronic effects of orally administered Bifidobacterium longum R0175 on the colonic microflora and bioavailability of OJ flavanones in healthy volunteers. In an acute study volunteers drank OJ with and without the microencapsulated probiotic, whereas the chronic effects were examined when OJ was consumed after daily supplementation with the probiotic over 4 weeks. Bioavailability, assessed by 0-24h urinary excretion, was similar when OJ was consumed with and without acute probiotic intake. Hesperetin-O-glucuronides, naringenin-O-glucuronides, and hesperetin-3'-O-sulfate were the main urinary flavanone metabolites. The overall urinary excretion of these metabolites after OJ ingestion and acute probiotic intake corresponded to 22% of intake, whereas excretion of key colon-derived phenolic and aromatic acids was equivalent to 21% of the ingested OJ (poly)phenols. Acute OJ consumption after chronic probiotic intake over 4 weeks resulted in the excretion of 27% of flavanone intake, and excretion of selected phenolic acids also increased significantly to 43% of (poly)phenol intake, corresponding to an overall bioavailability of 70%. Neither the probiotic bacterial profiles of stools nor the stool moisture, weight, pH, or levels of short-chain fatty acids and phenols differed significantly between treatments. These findings highlight the positive effect of chronic, but not acute, intake of microencapsulated B. longum R0175 on the bioavailability of OJ flavanones.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>États-Unis</li></country><region><li>Californie</li><li>Géorgie (États-Unis)</li></region></list><tree><country name="Espagne"><noRegion><name sortKey="Pereira Caro, Gema" sort="Pereira Caro, Gema" uniqKey="Pereira Caro G" first="Gema" last="Pereira-Caro">Gema Pereira-Caro</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Oliver, Christine M" sort="Oliver, Christine M" uniqKey="Oliver C" first="Christine M" last="Oliver">Christine M. Oliver</name></noRegion><name sortKey="Augustin, Mary Ann" sort="Augustin, Mary Ann" uniqKey="Augustin M" first="Mary Ann" last="Augustin">Mary Ann Augustin</name><name sortKey="Conlon, Michael" sort="Conlon, Michael" uniqKey="Conlon M" first="Michael" last="Conlon">Michael Conlon</name><name sortKey="Lockett, Trevor" sort="Lockett, Trevor" uniqKey="Lockett T" first="Trevor" last="Lockett">Trevor Lockett</name><name sortKey="Sanguansri, Luz" sort="Sanguansri, Luz" uniqKey="Sanguansri L" first="Luz" last="Sanguansri">Luz Sanguansri</name><name sortKey="Singh, Tanoj" sort="Singh, Tanoj" uniqKey="Singh T" first="Tanoj" last="Singh">Tanoj Singh</name><name sortKey="Weerakkody, Rangika" sort="Weerakkody, Rangika" uniqKey="Weerakkody R" first="Rangika" last="Weerakkody">Rangika Weerakkody</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Borges, Gina" sort="Borges, Gina" uniqKey="Borges G" first="Gina" last="Borges">Gina Borges</name></region><name sortKey="Crozier, Alan" sort="Crozier, Alan" uniqKey="Crozier A" first="Alan" last="Crozier">Alan Crozier</name><name sortKey="Roberts, Susan A" sort="Roberts, Susan A" uniqKey="Roberts S" first="Susan A" last="Roberts">Susan A. 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